X-Pure GelMA

What is X-Pure GelMA? 

X-Pure® GelMA is the world’s first gelatin methacryloyl (GelMA or GelMOD) produced under GMP conditions1, making it suitable for clinical applications in advanced biomedical applications. 

This premium biomaterial is ideal for 3D bioprinting, regenerative medicine and tissue engineering owing to its guaranteed ultra-low impurity levels, batch to batch consistency and tunable mechanical properties. As a result, X-Pure GelMA can reduce the development time between bench and bedside, for pharmaceuticals, medical devices and Advanced Therapy Medicinal Products (ATMP). 

Rousselot X-Pure GelMA portfolio

ProductMW (kDa)DoM (%)Endotoxin Level (EU/g)MA (ppm)Research GradeGMP grade
X-Pure GelMA 160P4016040<10 <30 1-100gAvailable upon request
X-Pure GelMA 160P6060<10 <30
X-Pure GelMA 160P8080<10 <30
X-Pure GelMA
90P40
9040<10 <30
X-Pure GelMA
90P60
60<10 <30
X-Pure GelMA
90P80
80<10 <30
X-Pure GelMA customCustomCustom<10 <30

Need a custom or GMP biomaterial?

OR a research or technical grade gelatin?

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How X-Pure GelMA works 

A GelMA hydrogel allows the formation of 3D architectures that are stable at body temperature. X-Pure GelMA rheological properties can be customized by varying the degree of modification (the number of crosslinks between gelatin protein chains) and the gelatin molecular weight, making it one of the most versatile hydrogels available for 3D cell culture and drug delivery systems2

Discover X-Pure GelMA

Watch our video to find out how GelMA is made and how it can be used for tissue engineering, drug delivery & other applications. 

Applications of X-Pure GelMA 

With ultra-low endotoxin levels, Rousselot’s X-Pure GelMA is suitable for the most sensitive biomedical & pharmaceutical applications, such as: 

View our customer product pipeline to see the medical devices and pharmaceuticals currently in development using X-Pure products.

Advantages of X-Pure GelMA  

Rousselot’s X-Pure GelMA stands out by offering several unique advantages. 

High batch-to-batch consistency 

The X-Pure GelMA standardized production process allows for high reproducibility and controllability in terms of composition and biophysiochemical properties. Lower material variability means a higher signal-to-noise ratio for your trials. 

Figure 2: Producing GelMA at the lab scale based on processes described in the literature often results in products with a high variability in methacryloyl functionalization and molecular weight, causing variable mechanical properties. This can mainly be attributed to the lack of process controls at lab scale. The same variability however is also seen in many commercial GelMA products, which use a similar process.

Find out more in our video: No more batch lottery when making a new GelMA 

Ultra-purified, suitable for sensitive applications 

Rousselot’s process securely removes precursor and process impurities, resulting in consistent and ultra-low impurity levels, making X-pure GelMA gelatins suitable for sensitive applications. 

Figure 3: Analysis of commercially available GelMA products shows a high and variable level of soluble impurities such as LPS, Methacrylic acid (MA) and DNA, and even insoluble debris in all products (pellets after centrifugation of 1-ml of 8% w:w solutions).

Find out more in our video: X-Pure - Bridging the valley of death 

GMP grade & scalable production process

X-Pure GelMA is the first commercially available GMP GelMA.  X-Pure Research grade and X-Pure GMP grade are functional equivalence products, meaning requalification efforts when switching to the GMP product can be avoided. This can accelerate translation from lab to clinic. 

To find out more about GMP grade GelMA, click here.

Reach out to our expert team for more info on co-innovation or formulation

Tunability:  

GelMA hydrogels can be synthesized with a specific degree of functionalization (DoM) and molecular weight (MW) or adjusted to the intended application. 

Figure 4: Graph to show how different cells require different environments